Excess levels of glucocorticoids in the body cause a range of clinical signs that include:

• Polydipsia
• Polyuria
• Polyphagia
• Hypertension
• Pot belly
• Thinning of the skin
• Hair loss
• Recurrent skin diseases
• Lethargy
• Excessive panting

Other less common clinical signs include*:

• Heat intolerance
• Seborrhea
• Comedones
• Hyperpigmentation
• Calcinosis cutis
• Bruising
• Testicular atrophy
• Failure to cycle
• Clitoral hypertrophy
• Facial paralysis

Some signs of Cushing’s syndrome may be confused with normal aging, which can make it particularly difficult to diagnose. Several tests are available to aid in the diagnosis of Cushing's syndrome. However, because cortisol levels in the blood of both normal dogs and dogs with hyperadrenocorticism fluctuate greatly throughout the day, a diagnosis cannot be confirmed by simply measuring the concentration of cortisol in the blood.

There are a number of diagnostic tests for Cushing’s sydrome available, including the ACTH Stimulation Test, Low-Dose Dexamethasone Suppression Test, and Urinary Cortisol:Creatinine Ratio.

More information about these tests can be obtained by contacting Dechra Technical Support at 866-933-2472 or support@dechra.com.

*Reusch CE (2005). Hyperadrenocorticism. Textbook of Veterinary Internal Medicine, 6th Ed., Ed SJ Ettinger, EC Feldman, pp. 1592-1612.