If a dog has previously been treated with mitotane, its adrenal function is reduced. Experience in the field suggests that mitotane therapy should be stopped for at least a month (or until the clinical signs of hyperadrenocorticism start to recur) and treatment with VETORYL Capsules should not be started until the post-ACTH serum cortisol is >9.1 µ/dL (>250 nmol/L). Close monitoring of adrenal function is advised, as these dogs may be more susceptible to the effects of trilostane.

The risk of hyperkalemia developing should be considered if trilostane is used in conjunction with potassium-sparing diuretics or ACE inhibitors (i.e., drugs that interfere with aldosterone production).

VETORYL Capsules were administered concurrently with a variety of medications that are commonly dispensed to middle-aged and geriatric dogs.The most commonly dispensed concurrent medications include heartworm prophylaxis, flea and tick treatments, routine vaccinations, antimicrobials, levothyroxine, non-steroidal anti-inflammatories, and joint supplements.